anti-Trimethyl-Histone H4 (Lys20), Rabbit Monoclonal (RM208)

Product description: Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

Alternate Names/Synonyms: H4 K20me3

Product Type: Recombinant Antibody

Clone: RM208

Isotype: Rabbit IgG

Immunogen: A trimethyl-peptide corresponding to trimethyl-Histone H4 (Lys20).

Applications: ELISA, WB, Multiplex

Species Crossreactivity: All Vertebrates

Specificity: This antibodyreacts to Histone H4 trimethylated at Lysine 20 (K20me3). It may slightly cross react to dimethylated Lysine 20 (K20me2) at a higher concentration. No cross reactivity with non-modified Lysine 20, monomethylated Lysine 20 (K20me1), or other methylations in histone H4.

Concentration: 1 mg/ml

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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