anti-VISTA, Rabbit Monoclonal (RM503)

Product description: Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.

Alternate Names/Synonyms: B7-H5; V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation; Platelet Receptor Gi24; Stress-induced Secreted Protein-1; Sisp-1; V-set Domain-containing Immunoregulatory Receptor

Product Type: Recombinant Antibody

Clone: RM503

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the C-terminus of human VISTA.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse, Rat

Specificity: This antibody reacts to human, mouse or rat VISTA.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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