anti-ZAP70 (human), Rabbit Monoclonal (RM408)

Product description: ZAP70 is a member of the Syk tyrosine kinase family and plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place.

Alternate Names/Synonyms: Tyrosine-protein Kinase ZAP-70; 70 kDa zeta-chain Associated Protein; Syk-related Tyrosine Kinase

Product Type: Recombinant Antibody

Clone: RM408

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the N-terminus of human ZAP70.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human ZAP70.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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