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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Cardamonin
25 mg
photos non contractuelles
Détails Produit
Product description: Cardamonin is a calchone from Aplinia species (zingiberaceous plant species) with anti-cancer and anti-inflammatory, anti-nociceptive activity. Cardamonin suppresses NF-kappa nuclear translocation and Ik-Ba phosphorylation. It has been shown to suppress nitric oxide and prostaglandin E2 synthesis, to suppress cyclooxygenase-2 expression, and to inhibit NF-kappa signaling. It induces apoptosis in cancer cells, suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling and ameliorates insulin resistance. It has been shown to induce autophagy and an antiproliferative effect through JNK activation. It is an hTRPA1 antagonist and shows also anti-parasitic activity. Also shown inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Alternate Names/Synonyms: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; Alpinetin chalcone; (E)-2',4'-Dihydroxy-6'-methoxy-chalcone
CAS: 19309-14-9
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