B-Xpander™ CD40L (human) (rec.) (Animal Free)

Product Description: B-Xpander™ is a potent enhanced Multimeric human CD40L cytokine, for B cell activation, B cell expansion (proliferation) and cell therapy applications. In-house production using a proprietary protocol and a characterized and certified CHO cell line allows the supply of the most active Multimeric human CD40L proteins in GMP-like format. Interest in B cells has recently increased in immunotherapies using Engineered B cells or Tumor-Infiltrating Lymphocytes (TILs). However, current methods for B cell expansion are inefficient, time consuming and can lead to insufficient B cell numbers and persistent T cell exhaustion. Our B-Xpander™ protein improves current protocols for B cell stimulation by mimicking the natural interaction between CD40L and CD40 molecules on B cells. B-Xpander™ Quality Features: • Production in characterized and certified CHO cell line (for GMP-grade manufacturing)* • High Bioactivity tested by ELISA/Cell-based Assays • Verified Purity & Homogeneity by SEC • Low Endotoxin Level • Batch-to-Batch Consistency • Animal-component free Production • No cross-linking Reagents necessary

Alternate Names/Synonyms: MultimericCD40L™ (Animal Free); ACRP30headless:CD40L; ACRP30headless:CD154; ADIPOQ-CD40L; ACRP30headless:TNFSF5

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