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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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D-erythro-Dihydrosphingosine [Sphinganine]
5 mg
photos non contractuelles
Détails Produit
Product description: The metabolite sphinganine activates the CD4+ regulatory T (Treg) cells, which accumulate in the tumor microenvironment (TME) and suppress the immune system. Sphinganine activates the Treg cells by physically interacting with the transcription factor c-Fos, and consequently increasing Treg cell proliferation. Sphinganine is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine is an inhibitor of protein kinase C and phospholipases A2 and D. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers. Sphinganine has been proposed to function as a c-Src kinase inhibitor in a drug-induced cancer cell model.
Alternate Names/Synonyms: Sphinganine (d18:0); Dihydrosphingosine; (2S,3R)-2-Aminooctadecane-1,3-diol
CAS: 764-22-7
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