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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Irbesartan
250 mg
photos non contractuelles
Détails Produit
Product description: Irbesartan is an orally available angiotensin II type 1 (AT1) receptor antagonist (IC50 = 1.3 nM) with antihypertensive activity. It binds to AT1 receptor with >5000 times higher affinity compared to AT2 receptor. Irbesartan also elicits selective peroxisome proliferator-activated receptor gamma (PPARgamma)-modulating activity and exhibits metabolic, anti-inflammatory and antioxidative properties. Irbesartan inhibits the receptor for advanced glycation end-products (RAGE)/high mobility group box 1 (HMGB1) axis and maybe useful in prevention and treatment of various diseases. Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.
Alternate Names/Synonyms: 2-Butyl-3-[[2?-(2H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one; Avapro; BMS-186295; SR-47436
CAS: 138402-11-6
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