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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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MBIMPH F-Analog 1 . hydrochloride
1 mg
photos non contractuelles
Détails Produit
Product description: Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Alternate Names/Synonyms: MBIMPH Fluorinated Analog 1; 3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide
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