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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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MOTS-c (human)
1 mg
photos non contractuelles
Détails Produit
Product description: Mitochondria-derived peptide (MDP). Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice. Potential anti-obesity and anti-aging compound. Involved in cellular stress resistance by regulating the nuclear genome. During metabolic stress (serum or glucose deprivation or oxidative stress) translocates to the nucleus in an AMPK-dependent manner. In the nucleus, MOTS-c binds to the transcription factor NRF2 that is a stress-responsive transcription factor and activates anti-oxidative stress genes.
Alternate Names/Synonyms: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c; MOTS3
CAS: 1627580-64-6
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