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AVANTI POLAR LIPIDS , CYGNUS , LARODAN , ADIPOGEN , MYBIOSOURCE , SERVA NORDMARK, BIOWORLD, EDGEBIO , PANREAC APPLICHEM
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Piperlongumine
50 mg
photos non contractuelles
Détails Produit
Product description: Cytotoxic against tumor cell lines [3, 4, 5]. Induces necrosis and apoptosis in cancer cells [5, 9, 12]. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation [4, 6, 10]. Shows significant anxiolytic and antidepressant activities [7]. Promotes adipogenesis of 3T3-L1 cells [8]. Induces in vivo and in vitro mutagenicity in eukaryotic models [11]. Selectively kills cancer cells by targeting the stress response to ROS [12]. Shows in vitro schistosomicidal activity [13]. Selective inhibitor of human immunoproteasome. Targets the beta5i subunit (LMP7) (IC50=15µM) with minimal inhibition of human constitutive proteasome [14].
Alternate Names/Synonyms: Piplartine; 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone
CAS: 20069-09-4
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