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Unique Oxidative Stress Markers 

The Japan Institute for the Control of Aging (JaICA) has conducted research into control of aging since its foundation with the goal of contributing health promotion. As a result, the Institute succeeded in developing a DNA oxidative damage measuring kit, thus taking the lead for this field. The Institute now sells many research products related to oxidative stress. Such products are utilized in the fields of medicine, pharmacy, biochemistry, food sciences, etc. The Institute also performs assay services utilizing its unique technologies. Preventive medicine and anti-aging are receiving increased attention with the advancement of aging society. 

 

JaICA is engaged in the kit reagent business and assay service business. In the kit reagent business, the Institute develops and manufactures research reagents used for measuring oxidative stress markers. The monoclonal antibodies and ELISA kits are used for detecting products of oxidative damage caused by reactive oxygen species and are highly appreciated by customers worldwide. In the assay service business the Institute conducts urine and blood sample testing and performs antioxidant assays on food based on the products the Institute has developed and the analysis skills it has accumulated over many years. The interest in preventive medicine, anti-aging and functional food has increased in recent years. As a result, there has been a growing number of requests from hospitals, universities, research institutes, food manufacturers and pharmaceutical industries all over the world to analyze oxidative stress markers, aging-related hormones and minerals.


 
Oxidative Stress Markers Overview
 
Type Product Name Application Remark
       Urine        Serum      Tissue     






DNA
Oxidation

8-OHdG Check ELISA Kit
 

YES

YES
(animals)

-

The most popular oxidative stress marker.
Assay time: approx 3.5 hours.

8-OHdG Check ELISA Kit (High Sensitivity)

YES

YES
(animals)

YES
Lower detection limit for human serum, tissue and cultured cells.

anti-8-Hydroxy-2'-deoxyguanisine [8-OHdG], mAb (N45.1)
 

-

-

YES

Low cross reactivity to 8-OHGua/8-OHG.

anti-Thymidine Glycol [TG], mAb (2E8)

-

-

YES
DNA-specific oxidative stress marker.











Lipid
Oxidation

Hexanoyl-Lys [HEL] ELISA Kit

YES

YES

YES
New biomarker for early stage oxidation of n:6 polyunsaturated fatty acid.

anti-Hexanoyl-Lys [HEL], mAb (5F12)

-

-

YES
Immunohistochemistry, Western Blot and ELISA.

anti-Hydroxy-2-nonenal [4-HNE], mAb
(HNEJ-2)

 

-

-

YES

Popular lipid oxidantion marker.

anti-Acrolein [ACR], mAb (5F6)
 
-

 
YES

Immunohistochemistry, Western Blot and ELISA.
 

anti-Malondialdehyde [MDA], mAb (1F83)


-
 
YES

Immunohistochemistry and Western Blot

anti-4-Hydroxy-2-hexenal [4-HHE], mAb (HHE53)
 

-

 
YES

Immunohistochemistry 

anti-Crotonaldehyde [CRA], mAb (82D3)

-

-
 
YES

Immunohistochemistry 

anti-Methylglyoxal [MG], mAb (3C)



YES

Immunohistochemistry 

anti-7-Ketocholesterol [7-KC], mAb (35A)



YES

Biomarker for cholesterol oxidation.



Protein
Oxidation

Dityrosine [DT] ELISA Kit
 
YES

-

-
New biomarker specific for protein oxidation. Assay time: overnight + 1.5hours. 

anti-Dityrosine [DT], mAb (1C3)


 
YES

Immunohistochemistry, Western Blot and ELISA.

anti-Dibromo-tyrosine [DiBrY], mAb (3A5)


-
 
YES 

Inflammation-related protein oxidation marker. 

Antioxidant
Assay

Total Antioxidant Capacity [PAO] Test Kit


YES 
 
Food
Samples
Total antioxidant assay for serum, foods and beverages. Can detect both hydrophobic and hydrophilic antioxidants. 

New Trace Element Assay Kits Product Flyer
Calcium Colorimetric Assay Kit (Chlorophosphonazo-III Method) 

Zinc Colorimetric Assay Kit (5-Br-PAPS Method)

 

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Dityrosine [DT] ELISA Kit Dityrosine [DT] ELISA Kit 1 Kit Ref. JAI-KDT-010E Marque JAICA 741.00 H.T.
 
8-OHdG Check ELISA Kit 8-OHdG Check ELISA Kit 1 Kit Ref. JAI-KOG-200SE Marque JAICA 741.00 H.T.
 
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Hexanoyl-Lys [HEL] ELISA Kit Hexanoyl-Lys [HEL] ELISA Kit 1 Kit Ref. JAI-KHL-700E Marque JAICA 741.00 H.T.
 
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