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100 µg

Ref. AG-20A-0025-C100

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Neuf 240.00 H.T.
en stock


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Détails Produit

Product description: Monoclonal Antibody. Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot. Isotype: Rat IgG2akappa. Clone: MF333F. Applications: ELISA, ICC, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.

Alternate Names/Synonyms: Forkhead Box Protein P3; Scurfin

Product Type: Monoclonal Antibody

Clone: MF333F

Isotype: Rat IgG2akappa

Immunogen: Recombinant mouse FOXP3.

Applications: ELISA, ICC, IHC, WB

Species Crossreactivity: Mouse

Specificity: Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot.

Concentration: 1mg/ml

Formulation: Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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Literature References: Alternatively activated dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig: Y.Y. Lan, et al.; J. Immunol. 177, 5868 (2006) | Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice: M.J. Perone, et al.; J. Immunol. 177, 5278 (2006) | Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance: E. Ambrosino, et al.; Cancer Res. 66, 7734 (2006) | Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells: G. Raimondi, et al.; J. Immunol. 176, 2808 (2006) | Antimetastatic activity of a preventive cancer vaccine: P. Nanni, et al.; Cancer Res. 67, 11037 (2007) | Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance: H.R. Turnquist, et al.; J. Immunol. 178, 7018 (2007) | Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells: F. Casiraghi, et al.; J. Immunol. 181, 3933 (2008) | Suppression of autoimmune diabetes by soluble galectin-1: M.J. Perone, et al.; J. Immunol. 182, 2641 (2009) | Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen: C. Hayashi, et al.; J. Immunol. 189, 3681 (2012) | Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice: Y. Yamada, et al.; Diabetologia 55, 2238 (2012)